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Platelet Rich Plasma (PRP)

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RevivaMed Plastic Surgery / Integrative Medicine / Platelet Rich Plasma (PRP)


PRP is an innovative therapy that is being used for treating conditions such as Osteoarthritis in various joints, Hair loss and tissue rejuvenation. The procedure entails drawing blood from a patient and then spinning it in a centrifuge machine. This generates a layer of concentrated platelets and growth factors that can possibly reduce pain and regenerate damaged tissue such as tendon, cartilage, hair or improving the integrity of your skin.

The human body has an inherent ability to heal tissue, but in certain areas that capacity is diminishes. New cells are created all the time in the body, in order to replace old or damaged tissue, in most but not all areas with age, this capability decreases. Even in younger individuals, the capability is slight (e.g. knee cartilage when damaged).

Certain conditions, such as degenerative arthritis, can cause severe joint pain, and conventional medicine offers treatment that may mask the pain temporarily, but not alter the condition itself. With the help of regenerative medicine and options such as platelet rich plasma therapy (PRP), things are changing right now to repair damaged tissue.

Here is a partial list of the conditions PRP helps considerably

  • Hair Loss
  • Ankle sprains
  • Achilles tendinitis
  • Plantar Fasciitis
  • Muscle tears
  • Wrinkles
  • Tennis/ Golfer’s elbow
  • Shoulder tendinitis and Rotator Cuff Injury
  • Joint arthritis – hip, spine, knee, ankle, SI joint, elbow, wrist
  • Soft Tissue Injury – Tendonitis, meniscus tears in the knee, ligament sprains.
  • Sacroiliac Joint Pain

Because of their immense effects in treating conditions related to tendon, joint, or ligament damage and pain, platelets are frequently used in treating athletes and quite a few have already used this therapy to speed up the healing processes in their bodies, so they could get back to playing at a very high level.

Athletes such as Kobe Bryant, Tiger Woods, Rafael Nadal, Dwight Howard, and Hines Ward to name a few have benefited from PRP therapy over the years.

PRP Palette Rich Plasma
Non Surgical Treatments

How is PRP made?

Plasma makes up the liquid part of human blood, and it contains red cells, white cells, and platelets.

Platelets exist in the blood all the time. They play a vital role in blood clotting during an injury and with helping the repair process itself. Once activated, they start releasing proteins responsible for healing, called growth factors. When platelet rich plasma is administered to a person, these growth factors speed up the body’s normal healing capability and may push it farther than it would normally go.

Once the platelets are injected in the painful area, they start a powerful regenerative PRP for Knee Arthritis They start releasing growth factors, and these will increase blood flow to the area, and generate a healing process.

Also, the platelets and growth factors send out signals which calls in the body’s stem cells as well to promote healing. The damaged tissue is replaced by new cells.

Because Hair loss and osteoarthritis have few surefire treatments and there are minimal risks associated with platelet-rich plasma injections, some doctors believe PRP therapy is worth trying. Patients should keep in mind that PRP is not a cure-all, and it may be best used in combination with nonsurgical treatments and lifestyle changes, such as physical therapy, weight loss, bracing, and NSAIDs.

Complete References for Platelet-Rich Plasma (PRP) Therapy for Arthritis

  • Van Buul GM, Koevoet WLM, Kops N, et al. Platelet-rich plasma relea- sate inhibits inflammatory processes in osteoarthritic chondrocytes. Am J Sports Med. 2011;39:2362–2370.
  • Anitua E, Sanchez M, Nurden AT, et al. Platelet-released growth factors enhance the secretion of hyaluronic acid and induce hepatocyte growth factor production by synovial fibroblasts from arthritic patients. Rheuma- tology (Oxford). 2007;46:1769–1772.
  • The International Cellular Medical Society. Guidelines for the Use of Platelet Rich Plasma. Adopted 2011. Accessed August 15, 2013.
  • Graziani F, Ivanovski S, Cei S, Ducci F, Tonetti M, Gabriele M. The in vitro effect of different PRP concentrations on osteoblasts and fibroblasts. Clin Oral Implants Res. 2006 Apr;17(2):212-9. PubMed PMID: 16584418.
  • Dohan Ehrenfest DM, Bielecki T, Mishra A, Borzini P, Inchingolo F, Sammartino G, Rasmusson L, Evert PA. In search of a consensus terminology in the field of platelet concentrates for surgical use: platelet-rich plasma (PRP), platelet-rich fibrin (PRF), fibrin gel polymerization and leukocytes. Curr Pharm Biotechnol. 2012 Jun;13(7):1131-7. Review. PubMed PMID: 21740379.
  • Marx R, Garg A. Dental and craniofacial applications of platelet- rich plasma. Carol Stream: Quintessence Publishing Co, Inc.; 2005.
  • Sánchez M, Anitua E, Azofra J, Andía I, Padilla S, Mujika I. Comparison of surgically repaired Achilles tendon tears using platelet-rich fibrin matrices. Am J Sports Med. 2007 Feb;35(2):245-51.
  • Mishra AK, Skrepnik NV, Edwards SG, Jones GL, Sampson S, Vermillion DA, Ramsey ML, Karli DC, Rettig AC. Platelet-Rich Plasma Significantly Improves Clinical Outcomes in Patients With Chronic Tennis Elbow: A Double-Blind, Prospective, Multicenter, Controlled Trial of 230 Patients. Am J Sports Med. 2013 Jul 3. [Epub ahead of print] PubMed PMID: 23825183.
  • Kon E, Filardo G, Matteo BD, Marcacci M. PRP For the Treatment of Cartilage Pathology. Open Orthop J. 2013 May 3;7:120-8. doi: 10.2174/1874325001307010120. Print 2013. PubMed PMID: 23730375; PubMed Central PMCID: PMC3664439.
  • Center for Disease Control. Spotlight Osteoarthritis: Lifetime Risk of Symptomatic Knee Osteoarthritis. Updated October 20, 2010. Accessed October 22, 2013.
  • Halpern B, Chaudhury S, Rodeo SA, Hayter C, Bogner E, Potter HG, Nguyen J. Clinical and MRI outcomes after platelet-rich plasma treatment for knee osteoarthritis. Clin J Sport Med. 2013 May;23(3):238-9. doi: 10.1097/JSM.0b013e31827c3846. PubMed PMID: 23238250.
  • Raynauld JP, Martel-Pelletier J, Berthiaume MJ, et al. Long term eval- uation of disease progression through the quantitative magnetic reso- nance imaging of symptomatic knee osteoarthritis patients: correlation with clinical symptoms and radiographic changes. Arthitis Res Ther. 2006;8:21.
  • Kolata G. As Sports Medicine Surges, Hope and Hype Outpace Proven Treatments. The New York Times. Sept 4 2011. Accessed October 8, 2013.
  • Piper SL, Kramer JD, Kim HT, Feeley BT. Effects of local anesthetics on articular cartilage. Am J Sports Med. 2011 Oct;39(10):2245-53. doi: 10.1177/0363546511402780. Epub 2011 Apr 22. Review. PubMed PMID: 21515808.
  • Moseley JB, O’Malley K, Petersen NJ, Menke TJ, Brody BA, Kuykendall DH, Hollingsworth JC, Ashton CM, Wray NP. A controlled trial of arthroscopic surgery for osteoarthritis of the knee. N Engl J Med. 2002 Jul 11;347(2):81-8. PubMed PMID: 12110735.
  • Biologic Orthopedic Society. 2013. LinkedIn. Discussion Page: What should the total reimbursement be to a provider for platelet rich plasma (PRP) procedure including any cost of goods and services and the office visit? Retrieved September 24, 2013.
  • Zhu Y, Yuan M, Meng HY, Wang AY, Guo QY, Wang Y, Peng J. Basic science and clinical application of platelet-rich plasma for cartilage defects and osteoarthritis: a review. Osteoarthritis Cartilage. 2013 Aug 7. doi:pii: S1063-4584(13)00903-5. 10.1016/j.joca.2013.07.017. [Epub ahead of print] PubMed PMID: 23933379.
  • Drengk A, Zapf A, Sturmer EK, et al. Influence of platelet-rich plasma on chondrogenic differentiation and proliferation of chondrocytes and mes- enchymal stem cells. Cells Tissues Organs. 2009;189:317–326.
  • Descalzi F, Ulivi V, Cancedda R, Piscitelli F, Luongo L, Guida F, Gatta L, Maione S, Di Marzo V. Platelet-rich plasma exerts antinociceptive activity by a peripheral endocannabinoid-related mechanism. Tissue Eng Part A. 2013 Oct;19(19-20):2120-9. doi: 10.1089/ten.TEA.2012.0557. Epub 2013 Jun 6. PubMed PMID: 23578218.
  • ECRI Institute. AHRQ Healthcare Horizon Scanning System Potential High Impact Interventions: Priority Area 01: Arthritis and Nontraumatic Joint Disease. (Prepared by ECRI Institute under Contract No. HHSA290201000006C.) Rockville, MD: Agency for Healthcare Research and Quality. June 2013.
  • Taralyn M. McCarrel, Tom Minas, Lisa A. Fortier; Optimization of Leukocyte Concentration in Platelet-Rich Plasma for the Treatment of Tendinopathy. The Journal of Bone & Joint Surgery. 2012 Oct;94(19):e143 1-8.
  • Ferrari M, Zia S, Valbonesi M. A new technique for hemodilution, preparation of autologous platelet-rich plasma and intraoperative blood salvage in cardiac surgery. Int J Artif Organs. 1987;10:47–50.
  • Kajikawa Y, Morihara T, Sakamoto H, Matsuda K, Oshima Y, Yoshida A, Nagae M, Arai Y, Kawata M, Kubo T. Platelet-rich plasma enhances the initial mobilization of circulation-derived cells for tendon healing. J Cell Physiol. 2008 Jun;215(3):837-45. doi: 10.1002/jcp.21368. PubMed PMID: 18181148.
  • Mishra A, Pavelko T. Treatment of chronic elbow tendinosis with buffered platelet-rich plasma. Am J Sports Med. 2006 Nov;34(11):1774-8. Epub 2006 May 30. PubMed PMID: 16735582.
  • Smyth NA, Murawski CD, Fortier LA, Cole BJ, Kennedy JG. Platelet-rich plasma in the pathologic processes of cartilage: review of basic science evidence. Arthroscopy. 2013 Aug;29(8):1399-409. doi: 10.1016/j.arthro.2013.03.004. Epub 2013 May 11. PubMed PMID: 23669235.
  • Lee KS, Wilson JJ, Rabago DP, Baer GS, Jacobson JA, Borrero CG. Musculoskeletal applications of platelet-rich plasma: fad or future? AJR Am J Roentgenol. 2011 Mar;196(3):628-36. doi: 10.2214/AJR.10.5975. Review. PubMed PMID: 21343507.
  • Patel S, Dhillon MS, Aggarwal S, Marwaha N, Jain A. Treatment with platelet-rich plasma is more effective than placebo for knee osteoarthritis: a prospective, double-blind, randomized trial. Am J Sports Med. 2013 Feb;41(2):356-64. doi: 10.1177/0363546512471299. Epub 2013 Jan 8. PubMed PMID: 23299850.
  • Eckstein F, Cicuttini F, Raynauld JP, et al. Magnetic resonance imaging (MRI) of articular cartilage in knee osteoarthritis (OA): morphological assessment. Osteoarthr Cartilage. 2006;14:46–75.
  • Lee KS, Wilson JJ, Rabago DP, Baer GS, Jacobson JA, Borrero CG. Musculoskeletal applications of platelet-rich plasma: fad or future? AJR Am J Roentgenol. 2011 Mar;196(3):628-36. doi: 10.2214/AJR.10.5975. Review. PubMed PMID: 21343507.
  • Dragoo JL, Danial CM, Braun HJ, Pouliot MA, Kim HJ. The chondrotoxicity of single-dose corticosteroids. Knee Surg Sports Traumatol Arthrosc. 2012 Sep;20(9):1809-14. doi: 10.1007/s00167-011-1820-6. Epub 2011 Dec 21. PubMed PMID: 22186921.
  • Kirkley A, Birmingham TB, Litchfield RB, Giffin JR, Willits KR, Wong CJ, Feagan BG, Donner A, Griffin SH, D’Ascanio LM, Pope JE, Fowler PJ. A randomized trial of arthroscopic surgery for osteoarthritis of the knee. N Engl J Med. 2008 Sep 11;359(11):1097-107. doi: 10.1056/NEJMoa0708333. Erratum in: N Engl J Med. 2009 Nov 12;361(20):2004. PubMed PMID: 18784099.
  • Platelet Rich Plasma (PRP) Therapy Reimbursement Overview. Copyright © 2012 RS Medical.
  • Jang SJ, Kim JD, Cha SS. Platelet-rich plasma (PRP) injections as an effective treatment for early osteoarthritis. Eur J Orthop Surg Traumatol. 2013 Jul;23(5):573-80. doi: 10.1007/s00590-012-1037-5. Epub 2012 Jul 7. PubMed PMID: 23412170.
  • Santo F. Martinez, M.D. Practical Guidelines for Using PRP in the Orthopaedic Office. American Academy of Orthopaedic Surgeons. Published September 10, 2010. Accessed November 15, 2012.
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